Synthesis, characterization and antimicrobial activity of new silver complexes with N-heterocyclic carbene ligands

• Published in: Inorganica Chimica Acta 2010-11, Vol.363 (14), p.3803-3808
• Main Authors: Özdemir, İlknur, Demir, Serpil, Günal, Selami, Özdemir, İsmail, Arıcı, Cengiz, Ülkü, Dinçer
• Format: Article
• Language: English
• Subjects: Antimicrobial; Benzimidazol-2-ylidene; Medicinal inorganic chemistry; N-heterocyclic carbene; Silver(I)
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2010.07.034

Novel Ag(NHC)X type complexes (NHC = 1,3-dialkylbenzimidazol-2-ylidene) have been prepared and their antibacterial activity tested against the Gram (+)/(−) and fungal strains. Synthesis, structure, and antimicrobial studies of silver complexes of N-heterocyclic carbene (NHC) are reported. All the silver–NHC complexes ( 1a–f) were prepared from the benzimidazolium salts by the reactions with Ag 2O in dichloromethane as a solvent at room temperature. The new compounds characterized by 1H NMR, 13 C NMR, IR and elemental analysis techniques which support the proposed structures. Chloro[1-(2,4,6-trimethylbenzyl)-3-(methoxyethyl)benzimidazol-2-ylidene]silver(I) complex was structurally characterized by single-crystal X-ray diffraction. A series of new Ag–NHC complexes were screened for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a Candida albicans and Candida tropicalis.