Effects of a derivative thiazoline/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils

• Published in: Inorganica Chimica Acta 2011-01, Vol.366 (1), p.373-379
• Main Authors: Viñuelas-Zahínos, E., Luna-Giles, F., Torres-García, P., Rodríguez, A.B., Bernalte-García, A.
• Format: Article
• Language: English
• Subjects: Azine; Cadmium complexes; Crystal structure; Human neutrophils; Phagocytosis; Thiazoline
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2010.11.037

New cadmium(II) complexes with thiazoline derivative ligand were synthesized and structurally characterized. Their influence on the phagocytic activity of human neutrophils has also been studied and compared with inorganic salts and free ligand. [Display omitted] ► An imino–amino tautomerism not allow the coordination of two nitrogen atoms in azines. ► First study about phagocytosis in human neutrophils of cadmium complexes. ► Cadmium coordination compounds improve phagocytosis. The complexes [CdCl2(ATHTd)] (1) and [Cd(NO3)2(ATHTd)(H2O)] (2) [ATHTd=N-(2-acetyl-2-thiazoline)-N′-(2-thiazolidin-2-one) azine] have been synthesized and characterized by a variety of physico-chemical techniques. X-ray data indicate that in 1 the coordination geometry around the metal ion can be considered a distorted square pyramid with cadmium(II) cation coordinated to one tridentate ATHTd ligand and two chloride ligands. In the case of 2, the coordination environment around Cd(II) atom approximates to a distorted pentagonal bipyramid with the cadmium atom bonded to one tridentate ATHTd ligand, one water molecule, one monodentate nitrate ligand and one bidentate nitrate ligand. The structure of ATHTd in the complexes presents an amino-2-thiazoline form instead of the iminothiazolidine one observed in free ATHTd. Likewise, the degree of rotation of the thiazoline rings around the C(1)–C(4) and C(6)–N(3) bonds has changed in complexes, which permit the coordination through thiazolinic nitrogen atoms. Besides, we study the phagocytic function in human neutrophils treated with ligand ATHTd, CdCl2, Cd(NO3)2 and complexes 1 and 2. From the obtained results it can be concluded that the complexes 1 and 2 increase the phagocytic capacity of neutrophils with respect to Cd(II) salts and ATHTd.