Synthesis and characterization of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S)

• Published in: Inorganica Chimica Acta 2012-05, Vol.387, p.163-172
• Main Authors: Peruzzo, Valentina, Pretzsch, Cornelia, Tisato, Francesco, Porchia, Marina, Refosco, Fiorenzo, Marzano, Cristina, Gandin, Valentina, Schiller, Eik, Walther, Martin, Pietzsch, Hans-Jürgen
• Format: Article
• Language: English
• Subjects: Aminodiphosphines; Copper(I) complexes; Cytotoxic activity; Phosphorus NMR; Polydentate phosphines
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2012.01.012

Tetrahedral copper(I) complexes including newly synthesized tetradentate N-functionalised aminodiphosphines have been prepared and characterized. [Display omitted] ► Synthesis of tetradentate N-functionalised aminodiphosphines. ► Novel tetrahedral copper(I) complexes have been synthesized and characterized. ► The representative [Cu(PN(S)P)][BF4] complex has been evaluated as cytotoxic agent. Two series of novel tetrahedral copper(I) complexes comprising tridentate PNP-aminodiphosphines and tetradentate PN(X)P-substituted aminodiphosphines (X=O, S) have been prepared and characterized by conventional physico-chemical techniques. The first series includes ‘3+1’-type complexes comprising an aromatic PNP-aminodiphosphine and acetonitrile or triphenylphosphine. In the second series, the central amine function of the PNP-ligand was substituted with functionalized pendant arms containing ether, hydroxyl or thioether groups to enhance the chelation ability of the ligand. Fully coordinated neutral and cationic complexes were isolated. A preliminary study investigating both the labeling of 64Cu with the prototype PN(S)P ligand and the potential cytotoxic activity of the ‘cold’ [Cu(PN(S)P)][BF4] complex is reported.