Synthesis and characterization of (ethylenediamine)/(diammine)platinum(II) coordinated to seleno ligands containing carboxylic acid functionality

• Published in: Inorganica Chimica Acta 2012-04, Vol.385, p.185-189
• Main Authors: Chopade, Suresh M., Phadnis, Prasad P., Wadawale, Amey, Hodage, Ananda S., Jain, Vimal K.
• Format: Article
• Language: English
• Subjects: Diselenides; NMR; Platinum; Selenoethers; X-ray structure
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2012.01.055

The work deals with synthesis and characterization of an oxaliplatin analog, [Pt(en)(OOCCH2SeCH2COOH)][OH] containing selenium atom. Time dependant 195Pt{1H} NMR studies reveal that it binds completely with 5′-guanosine monophosphate (5′-GMP). [Display omitted] ► Analogues of oxaliplatin containing selenium atom were synthesized and characterized. ► Their reactivity with 5′-GMP was studied by time dependant 195Pt{1H} NMR spectroscopy. ► One of the compounds, [Pt(en)(OOCCH2SeCH2COOH)][OH] shows complete binding with 5′-GMP. The reaction of [Pt(N^N)(ONO2)2] with seleno ethers, Se{(CH2)nCOOH)}2 (n=1 or 2) in the presence of NaOH afforded complexes of composition [Pt(N^N)(OOC(CH2)nSe(CH2)nCOOH)][OH] (N^N=en or 2NH3; n=1 or 2). Similar reactions with diselenides, [Se(CH2)nCOOH]2 gave complexes of the type [Pt(en){OOC(CH2)nSe}2]. These complexes were characterized by microanalyses and NMR spectroscopy (1H, 13C{1H}, 77Se{1H} and 195Pt{1H}). The seleno ligand in [Pt(N^N)(OOC(CH2)nSe(CH2)nCOOH)][OH] is coordinated to platinum through one carboxylate group and a selenium atom. The molecular structure of [Pt(en)(OOCCH2SeCH2COOH)][OH] was established by single crystal X-ray diffraction analysis. The reactivity of [Pt(N^N)(OOC(CH2)nSe(CH2)nCOOH)][OH] with mononucleotide 5′-guanosine monophosphate (5′-GMP) has been studied in aqueous solution by 195Pt{1H} NMR spectroscopy.