Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes

Twelve new (salicylaldiminato)platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. •Six novel bis Schiff base platinum complexes have been prepared.•Six organometallic mono Schiff ba...

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Bibliographic Details
Published in:Inorganica Chimica Acta 2014-05, Vol.415, p.88-94
Main Authors: Patterson, Alyssa E., Miller, Jessica J., Miles, Brittany A., Stewart, Erin L., Melanson, Josée-Marie E.J., Vogels, Christopher M., Cockshutt, Amanda M., Decken, Andreas, Morin, Pier, Westcott, Stephen A.
Format: Article
Language:English
Subjects:
Cancer
Glioma
Platinum
Salicylaldimine
Schiff base
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Summary:Twelve new (salicylaldiminato)platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. •Six novel bis Schiff base platinum complexes have been prepared.•Six organometallic mono Schiff base platinum complexes also prepared.•Solubility problems with the bis Schiff base complexes complicated biotesting.•Addition of cyclooctene group increases solubility to organometallic complexes.•All new species showed cytotoxic activities against glioma cell lines. Twelve new (salicylaldiminato)platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. Initial biotesting was done on platinum complexes 1–6, which display a wide range of physicochemical properties. Whereas introduction of aromatic rings in the complexes did not seem to have a significant impact on bioactivities, the length of the aliphatic group positively correlated with cytotoxicity in all cell lines. Complexes 2 and 3 were found to be particularly potent against LN18 cells as demonstrated by stronger cell growth inhibition when compared to cisplatin. These initial findings led us to develop an additional series of mono (salicylaldiminato)platinum(II) complexes 7–12, which were subjected to additional cytotoxicity studies but were less cytotoxic compared to the bis Schiff base complexes. These organometallic compounds could serve as interesting starting points for the development of novel therapeutic strategies to treat brain tumors.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2014.02.028