Boron Containing Mono- and Bis-carboranethiolate Derivatives of Respective Formula [(bipy)MCl(CBT)] and [(bipy)M(CBT)2] (M = PdII, PtII)

• Published in: Inorganica Chimica Acta 2022-12, Vol.543, p.121160, Article 121160
• Main Authors: Pia Donzello, Maria, Bellucci, Noemi, Pettiti, Ida, Rizzoli, Corrado, Ercolani, Claudio
• Format: Article
• Language: English
• Subjects: New mono- and bis-CBT PdII and PtII complexes (CBT = m-carborane-1-thiolate anion). X-ray crystal structure and detailed UV-visible spectral features
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2022.121160

Synthesis and X-ray crystal structure of the species of formula [(bipy)MCl(CBT)]·0.5CH3CN (M = PdII, PtII) and [bipy)Pt(CBT)2] (CBT = m-carboranethiolate anion), of potential interest as anticancer agents in BNCT (boron neutron capture therapy). Detailed IR- and UV-visible spectra are also reported. [Display omitted] •New Pd(II) and Pt(II) carboranethiolate derivatives of potential interest in BNCT. X-ray crystal structure. Physico-chemical properties. Synthetic procedures are reported of the new “low molecular weight” mononuclear PdII and PtII derivatives of formula [(bipy)MCl(CBT)]·0.5CH3CN (M = PdII, PtII) and [(bipy)Pt(CBT)2] (CBT = m-carboranethiolate anion) evaluated of interest as potential anticancer agents in boron neutron capture therapy (BNCT). The structure of all three species has been elucidated by single-crystal X-ray work and further examined by IR and UV-visible spectral behavior. The detailed presentation of the spectral response for all of them in solution of low-donor non-aqueous solvents (CH3CN, DMF, DMSO) evidences the presence of a broad absorption in the region 400-500 nm, already previously observed for the species cis-[(bipy)Pd(CBT)2], this absorption interpreted as due to the presence of one or two metal-CBT environments in the related cis-structurally arranged mono- and bis-CBT derivatives.