Pharmaceutical properties of macrocyclic schiff base transition metal complexes: Urgent need in Today’s World

• Published in: Inorganica Chimica Acta 2023-02, Vol.546, p.121300, Article 121300
• Main Authors: Yadav, Monika, Yadav, Deepak, Pal Singh, Dharam, Kumar Kapoor, Jitander
• Format: Article
• Language: English
• Subjects: Anti-cancer and Template synthesis; Anti-microbial; Biological activity; Macrocyclic Schiff base complexes
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2022.121300

[Display omitted] •Review of Macrocyclic transition metal complexes synthesized in the last two decades.•Macrocyclic Schiff bases and metal complexes and pharmacological significance.•Different methods for synthesis of these complexes.•Cytotoxic properties of these complexes against various cancer cells.•Anti-microbial effects of the complexes against various bacterial and fungal strains. The World is facing an epidemic of various diseases caused by viruses, bacteria, and fungi. Apart from it, cancer, malaria, and diabetes are some major health problems. So, a need arises to discover novel molecules that can be used as therapeutic drugs for several diseases, including cancer and diabetes. Macrocyclic Schiff base (MSB) transition metal complexes are popularly studied organometallic compounds due to their vast biological applications in treating infectious diseases and various health problems. This attracts the researchers to the Chemistry of Schiff base metal complexes in pharmaceutical applications and areas like biochemical, bio-inorganic, environmental, industrial, photochemical, photophysical, photoelectronic etc. So, the Novel synthesis of Schiff base metal complexes will design and develop more effective therapeutic drugs. Even though the topic is quite old and exploited, many researchers are still globally working to find new MSB complexes and their applications. Based on the above considerations, we have reviewed the pharmaceutical properties of MSB transition metal complexes synthesized in the last two decades.