Antiproliferative and antimycobacterial effects of mononuclear palladium(II) complexes with N-heterocyclic ligands

• Published in: Inorganica Chimica Acta 2023-10, Vol.556, p.121649, Article 121649
• Main Authors: Uvarova, Marina A., Baravikov, Dmitry E., Dolgushin, Fedor M., Aliev, Teimur M., Titov, Konstantin O., Bekker, Olga B., Lashkin, Arseniy I., Malyants, Irina K., Shender, Victoria O., Kiskin, Mikhail A., Eremenko, Igor L., Lutsenko, Irina A.
• Format: Article
• Language: English
• Subjects: Coordination compounds; Crystal structure; Mycolicibacterium smegmatis; Palladium(II); SKOV3
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2023.121649

[Display omitted] A series of mononuclear palladium(II) coordination compounds with N-heterocyclic ligands – 1,10-phenanthroline (phen), pyrazole (Hpz), 3,5-dimethylpyrazole (Hdmpz), and anions of 2-/3-furoic (2-Hfur and 3-Hfur) and trifluoromethanesulfonic (Hotf) acids were obtained. According to the single-crystal X-ray diffraction analysis data in complexes [Pd(Hdmpz)4]·2L (L = 2-fur (1); 3-fur (2)), [Pd(3-fur)2(phen)]·H2O (3) and [Pd(Hpz)2(phen)]·2otf (4), the cation has a square planar environment of N-, O-donor atoms {PdN4} for 1, 2, 4 and {PdN2O2} for 3. The cytotoxic effect of various concentrations of complexes 2, 3 and 4 on human ovarian adenocarcinoma cells (SKOV3) and human dermal fibroblasts (HDF) was measured in vitro. Complex 4 displayed antiproliferative activity against ovarian adenocarcinoma cells, with a six-fold weaker effect on healthy fibroblasts. The antimycobacterial activity of compounds 2–4 was determined in vitro against a non-pathogenic Mycolicibacterium smegmatis strain.