Silver(I) complexes with diorganochalcogen ligands of type (2-MeC6H4CH2)2E (E = S, Se). Synthesis, structure and antiproliferative activity

• Published in: Inorganica Chimica Acta 2024-05, Vol.565, p.121972, Article 121972
• Main Authors: Corjuc, Lavinia, Pop, Alexandra, Licarete, Emilia, Banciu, Manuela, Silvestru, Anca
• Format: Article
• Language: English
• Subjects: Antiproliferative activity; Coordination behaviour; Diorganochalcogen ligands; Silver(I) complexes; Structural characterization
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2024.121972

Silver(I) complexes of type [Ag(X){E(CH2C6H4Me-2)2}n] (E = S, Se; X = CF3SO3, NO3, ClO4, n = 1, 2) were prepared and structurally characterized both in solution and in solid state. The complexes with AgOTf moieties showed promising in vitro antiproliferative activity against the murine melanoma B16.F10 cells. [Display omitted] •Ag(I) complexes: [Ag(X){E(CH2C6H4Me-2)2}n] [E = S, Se; X  = OTf, NO3, ClO4; n = 1,2]•1:1 electrolytes in MeOH solution.•Se→Ag coordination.•supramolecular associations by O···Ag, O···H and π H···Cg secondary bonding.•In vitro antiproliferative activity against murine melanoma B16.F10 cells. Silver(I) complexes of types [Ag(X){E(CH2C6H4Me-2)2}] [E = S, X  = CF3SO3 (1), NO3 (2), ClO4 (3); E = Se, X  = CF3SO3 (4), NO3 (5), ClO4 (6)] and [Ag(X){E(CH2C6H4Me-2)2}2] [X = CF3SO3, E = S (7), Se (8); X  = ClO4, E = S (9), Se (10)] were prepared by reacting the diorganochalcogenides (2-MeC6H4CH2)2E [E = S (L1), Se (L2)] with the appropriate silver(I) salt in a 1:1 and a 2:1  molar ratio, respectively. The ligands and the Ag(I) complexes were characterized by multinuclear NMR spectroscopy (1H, 13C{1H}, 19F{1H}, 77Se{1H}, as appropriate), ESI+ mass spectrometry, elemental analysis and IR spectroscopy. The crystal and molecular structures of the ligand L1 and the complexes 2, 5, 7, 8 and 9 were determined by single-crystal X-ray diffraction. The molar conductivity of the reported metal complexes showed their behaviour as 1:1 electrolytes in solution, while in solid state the inorganic anionic ligand is coordinated to silver by OAg bonds. Preliminary results showed that the silver(I) complexes bearing triflato ligands have in vitro promising antiproliferative activity against the murine melanoma B16.F10 cells.