Adaptive evolution on HA1 subunit of influenza B virus

Some studies on the influenza AH3 viruses showed that a small number of codons in the HA1 had been under positive selection. However, the existence of amino acid sites under positive selective pressure in the influenza B HA1 subunit has not been a major issue of study. In this work it was used as th...

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Bibliographic Details
Published in:International Congress series 2004-06, Vol.1263, p.691-694
Main Authors: Nunes, Baltazar, Pechirra, Pedro, Castro, Luisa Canto e, Rebelo-de-Andrade, Helena
Format: Article
Language:English
Subjects:
Adaptive evolution
Haemagglutinin
Influenza B
Selective pressure
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Summary:Some studies on the influenza AH3 viruses showed that a small number of codons in the HA1 had been under positive selection. However, the existence of amino acid sites under positive selective pressure in the influenza B HA1 subunit has not been a major issue of study. In this work it was used as the parameter, ω= d N/ d S (acceptance rate of non-synonymous substitutions), to test the hypothesis of the existence of adaptive evolution on the HA1 subunit of influenza B and identify the codons more likely to be under positive selective pressure. The data were related to 80 HA1 segments of the haemagglutinin gene of influenza B virus. For the sequence analysis, codon-substitution models for heterogeneous selective pressure at amino acid sites were used. The maximum likelihood estimates were obtained (package PAML 3.13a) for the models referred to as M0 to M8 [Genetics, 155 (2000) 431]. The model with better results was the M3, estimating a percentage of 97.4% of the codon under negative selective pressure (65.9% with ω
ISSN:0531-5131
1873-6157
DOI:10.1016/j.ics.2004.02.069