Rapid identification of novel influenza virus genetic variants in surveillance by routine sequencing

The rapid antigenic drift of human influenza viruses necessitates annual reevaluation of vaccine composition, and time may be short between the start of the outbreaks and the time when the next season's vaccine strains need to be determined. The application of genetic characterisation shortly a...

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Bibliographic Details
Published in:International Congress series 2004-06, Vol.1263, p.695-698
Main Authors: Hungnes, Olav, Krogh, Grethe H, Ørstavik, Ivar, Samdal, Helvi Holm
Format: Article
Language:English
Subjects:
Evolution
Influenza
Surveillance
Vaccine
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Summary:The rapid antigenic drift of human influenza viruses necessitates annual reevaluation of vaccine composition, and time may be short between the start of the outbreaks and the time when the next season's vaccine strains need to be determined. The application of genetic characterisation shortly after virus detection may accelerate the detection of epidemiological trends like the emergence of novel viruses. Further antigenic characterisation and steps to obtain candidate vaccine strains may then be taken in a more selective and efficient manner. We describe here the early detection of novel influenza B and A(H3N2) genetic variants in the Norwegian influenza surveillance during the 2001/2002 and 2002/2003 seasons.
ISSN:0531-5131
1873-6157
DOI:10.1016/j.ics.2004.02.094