Does contrast ultrasonography damage liver cell?

To confirm whether the microbubble activated by sonication causes liver damage, the authors performed two experiments. Experiment 1 followed Shigeta's experiment. As an ultrasound contrast agent (UCA), Levovist was used and sonicated by Acuson Sequoia™ 512 by Siemens. Wister rats of 300 g were...

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Bibliographic Details
Published in:International Congress series 2004-10, Vol.1274, p.147-150
Main Authors: Takada, A. Etsuo, Kudo, Nobuki, Endoh, Nobuyuki, Hachiya, Hiroyuki, Takeuchi, Shinichi, Tuchiya, Takenobu, Natori, Michiya, Yamaguchi, Keiichiro
Format: Article
Language:English
Subjects:
Liver damage
Microbubble
Ultrasonic contrast agent
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Summary:To confirm whether the microbubble activated by sonication causes liver damage, the authors performed two experiments. Experiment 1 followed Shigeta's experiment. As an ultrasound contrast agent (UCA), Levovist was used and sonicated by Acuson Sequoia™ 512 by Siemens. Wister rats of 300 g were divided into four groups: (A) administration of ultrasonic contrast agent (UCA) and ultrasonic exposure, (B) administration of UCA, (C) ultrasonic exposure, and (D) control. Experiment 1 did not show the evidence of hepatic damage such as Shigeta et al. reported. Hence, we conducted Experiment 2 with a much higher acoustic output. But no clear damage was observed in both optical and electron microscopic specimens.
ISSN:0531-5131
1873-6157
DOI:10.1016/j.ics.2004.07.017