Pregnancy-associated plasma protein-A gene polymorphisms in patients with periodontitis

Pregnancy associated plasma protein-A (PAPP-A) is a high-molecular zinc-binding metalloproteinase primarily produced by the placental syncytiotrophoblast during pregnancy. Proinflammatory cytokines were potent stimulators of PAPP-A expression in cultured human cells. PAPP-A gene polymorphisms are as...

Full description

Saved in:
Bibliographic Details
Published in:International dental journal 2024-10, Vol.74, p.S269-S270
Main Authors: Çelenk, Berra, Özener, Hafize Öztürk, Aslan, Beste Tacal, Yılmaz, Özlem Özge, Kuru, Leyla
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pregnancy associated plasma protein-A (PAPP-A) is a high-molecular zinc-binding metalloproteinase primarily produced by the placental syncytiotrophoblast during pregnancy. Proinflammatory cytokines were potent stimulators of PAPP-A expression in cultured human cells. PAPP-A gene polymorphisms are associated with inflammatory diseases, however no data are available regarding periodontal disease. This study aims to evaluate the relationship between PAPP-A gene polymorphism and stage 3 grade B and C (S3GBC) periodontitis. A total of 226 systemically healthy subjects, consisted of 112 S3GBC periodontitis patients (P group) and 114 periodontally healthy individuals (H group) were included in this study. Demographic data, plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level were recorded. Genomic DNA was obtained from peripheral blood of individuals. Genotype for PAPP-A rs7020782 polymorphism was determined using real-time polymerase chain reaction. Data were analysed using Chi-square and Mann-Whitney U tests, and p
ISSN:0020-6539
DOI:10.1016/j.identj.2024.07.198