Salivary Expression of Basic Fibroblast Growth Factor

Basic fibroblast growth factor (bFGF) - a cytokine that is sometimes also referred to as FGF2. It is identified as a strong factor for proliferation and migration of fibroblasts. It also promotes capillary formation and accelerates the tissue regeneration (1, 2). The aim of this study is to evaluate...

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Bibliographic Details
Published in:International dental journal 2024-10, Vol.74, p.S57-S57
Main Authors: Roghay, Shafaq Saeed, Butt, Saima Akram, Batool, Dr Hira
Format: Article
Language:English
Online Access:Get full text
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Summary:Basic fibroblast growth factor (bFGF) - a cytokine that is sometimes also referred to as FGF2. It is identified as a strong factor for proliferation and migration of fibroblasts. It also promotes capillary formation and accelerates the tissue regeneration (1, 2). The aim of this study is to evaluate levels of bFGF in saliva of healthy controls and in cases with potential oral premalignant epithelial lesions. This study included 90 controls and 90 cases with potential pre-malignant oral epithelial lesions. Socio - demographic data was recorded for all the study participants using a questionnaire. An intraoral examination was also done and the daily frequency and total extent of tobacco usage (in years) was also recorded. Clinical parameters were evaluated for all the potential pre-malignant oral epithelial lesions and levels of salivary bFGF were investigated using ELISA technique. The saliva collected from all the cases indicated occurrence of bFGF. On analysis, significant association (p< 0.0001) was observed between salivary levels of bFGF in controls and diseased cases. It can be concluded that elevated levels of bFGF can reflect the irreversible progression in potential pre-malignant oral epithelial lesions.
ISSN:0020-6539
DOI:10.1016/j.identj.2024.07.743