Angiogenesis in Prevascularized Biomaterials: an in silico study

An agent-based model is developed to simulate angiogenesis in porous biomaterial scaffolds. This study investigates the influence of the existence of preperformed capillaries within the scaffolds on angiogenesis. Different configurations of capillary structures were tested and compared with empty sc...

Full description

Saved in:
Bibliographic Details
Published in:IFAC-PapersOnLine 2015-09, Vol.48 (20), p.395-400
Main Authors: Bayrak, Elif Seyma, Xiao, Nan, Somo, Sami I., Akar, Banu, Mehdizadeh, Hamidreza, Brey, Eric M., Cinar, Ali
Format: Article
Language:English
Subjects:
Agent-based modeling
angiogenesis
prevascularized scaffolds
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An agent-based model is developed to simulate angiogenesis in porous biomaterial scaffolds. This study investigates the influence of the existence of preperformed capillaries within the scaffolds on angiogenesis. Different configurations of capillary structures were tested and compared with empty scaffolds. Simulation results indicate that prevascularization of scaffolds before implantation supports rapid and stable blood vessel network development. The results were consistent with experimental studies from the literature.
ISSN:2405-8963
2405-8963
DOI:10.1016/j.ifacol.2015.10.172