In vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens

Highlights • We examined the in vitro antimicrobial activity of WQ-3810. • The activity of WQ-3810 was potent against multidrug-resistant A. baumannii. • WQ-3810 was also active against fluoroquinolone-resistant E. coli and S. pneumoniae. • Its potent activity could be due to its strong inhibition o...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2014-11, Vol.44 (5), p.443-449
Main Authors: Kazamori, Daichi, Aoi, Hiroshi, Sugimoto, Kaori, Ueshima, Taichi, Amano, Hirotaka, Itoh, Kenji, Kuramoto, Yasuhiro, Yazaki, Akira
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antimicrobial resistance
DNA Gyrase - metabolism
Drug Resistance, Multiple, Bacterial
Fluoroquinolones
Fluoroquinolones - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - isolation & purification
Humans
Infectious Disease
Microbial Sensitivity Tests
WQ-3810
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Summary:Highlights • We examined the in vitro antimicrobial activity of WQ-3810. • The activity of WQ-3810 was potent against multidrug-resistant A. baumannii. • WQ-3810 was also active against fluoroquinolone-resistant E. coli and S. pneumoniae. • Its potent activity could be due to its strong inhibition of the target enzymes.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2014.07.017