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Pyrazole-based compounds in chitosan liposomal emulsion for antimicrobial cotton fabrics

The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-Phenyl pyrazole-3, 5-diamine, 4...

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Bibliographic Details
Published in:International journal of biological macromolecules 2018-02, Vol.107 (Pt A), p.585-594
Main Authors: Nada, Ahmed, Al-Moghazy, Marwa, Soliman, Ahmed A.F., Rashwan, Gehan M.T., Eldawy, Taghreed Hosny Ahmed, Hassan, Ashraf Abd Elhakim, Sayed, Galal Hosni
Format: Article
Language:English
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Summary:The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. 1-Phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] and 1H- pyrazole-3 (1), 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (2) were synthesized, characterized and encapsulated into liposomal chitosan emulsions for textile finishing. The chemical modifications of cotton fabrics were demonstrated by infrared analysis. Retention of the fabric mechanical properties was investigated by reporting the tensile strength values. Synthesized pyrazole-based compounds were screened for cytotoxicity against skin fibroblast cell line and showed very limited toxicity for both compounds. Antimicrobial potentials of the treated cotton fabrics were tested against bacterial strains E. coli ATCC 8379 and Staphylococcus aureus ATCC 25923.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2017.09.031