Potential of novel electrospun core-shell structured polyurethane/starch (hyaluronic acid) nanofibers for skin tissue engineering: In vitro and in vivo evaluation

The biomaterials with excellent biocompatibility and biodegradability ¬can lead to satisfactory wound healing. In this study, core-shell structured PU (polyurethane)/St (Starch) and PU/St (Hyaluronic Acid (HA)) nanofibers were fabricated with coaxial electrospinning technique. The morphology charact...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-03, Vol.146, p.627-637
Main Authors: Movahedi, Mehdi, Asefnejad, Azadeh, Rafienia, Mohammad, Khorasani, Mohammad Taghi
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Cell Line
Core-Shell Nanofibers
Fibroblasts
Hyaluronic acid
Hyaluronic Acid - chemistry
Male
Materials Testing
Mice
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanofibers - chemistry
Polyurethane
Polyurethanes - chemistry
Rats
Skin - diagnostic imaging
Skin - pathology
Starch - chemistry
Tissue Engineering - methods
Tissue Scaffolds - chemistry
Wound Healing
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Summary:The biomaterials with excellent biocompatibility and biodegradability ¬can lead to satisfactory wound healing. In this study, core-shell structured PU (polyurethane)/St (Starch) and PU/St (Hyaluronic Acid (HA)) nanofibers were fabricated with coaxial electrospinning technique. The morphology characterization of the core-shell structure of nanofibers was investigated by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. Contact-angle measurements were confirmed the core/shell structure of the electrospun nanofibers with shell and core feed rates of 0.675 L/min and
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2019.11.233