Topical administration of pullulan gel accelerates skin tissue regeneration by enhancing collagen synthesis and wound contraction in rats

Here, we have studied the efficacy of pullulan gel on wound healing by performing biochemical, biophysical and histological investigations. A 2 cm2 open excision wound was made on the dorsum of the rats and topically treated with 500 μL of pullulan gel. The control group was left untreated. The povi...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-04, Vol.149, p.395-403
Main Authors: Thangavel, Ponrasu, Vilvanathan, Sangeetha Priya, Kuttalam, Iyappan, Lonchin, Suguna
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Topical
Animals
Collagen
Gels - chemistry
Gels - pharmacology
Glucans - chemistry
Glucans - pharmacology
Humans
Plant Extracts - chemistry
Plant Extracts - pharmacology
Pullulan
Rats
Skin - drug effects
Skin - pathology
Skin Aging - drug effects
Skin Aging - pathology
Wound healing
Wound Healing - drug effects
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Summary:Here, we have studied the efficacy of pullulan gel on wound healing by performing biochemical, biophysical and histological investigations. A 2 cm2 open excision wound was made on the dorsum of the rats and topically treated with 500 μL of pullulan gel. The control group was left untreated. The povidone-iodine (PI) ointment treated animals were considered as positive control. The granulation tissues formed were collected at different time point intervals and used for various biochemical, biophysical and histological analyses. Biochemical analyses revealed that pullulan gel significantly (p 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.01.187