Co-culture of mesenchymal stem cells and human umbilical vein endothelial cells on heparinized polycaprolactone/gelatin co-spun nanofibers for improved endothelium remodeling

Endothelization of a tissue-engineered substrate is important for its application as an artificial vascular graft. Despite recent advancements in artificial graft fabrication, a graft of

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-05, Vol.151, p.186-192
Main Authors: Joshi, Akshat, Xu, Zhe, Ikegami, Yasuhiro, Yamane, Soichiro, Tsurashima, Masanori, Ijima, Hiroyuki
Format: Article
Language:English
Subjects:
Cell Differentiation
Co-axial electrospinning
Coculture Techniques
Core-shell nanofibers
Cytoskeleton - chemistry
Cytoskeleton - metabolism
Endothelium
Fluorescent Antibody Technique
Gelatin - chemistry
Heparin - chemistry
Human Umbilical Vein Endothelial Cells - metabolism
Humans
Mesenchymal Stem Cells - cytology
Nanofibers - chemistry
Nanofibers - ultrastructure
Polyesters - chemistry
Tissue Engineering
Tissue Scaffolds - chemistry
Vascular tissue engineering
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Summary:Endothelization of a tissue-engineered substrate is important for its application as an artificial vascular graft. Despite recent advancements in artificial graft fabrication, a graft of
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.02.163