Techno-functional characterization of chitosan nanoparticles prepared through planetary ball milling

Planetary ball milling of chitosan microparticles (CMP) for 8 h produced chitosan nanoparticles (CNP) having hydrodynamic diameter of 615.18 nm. The ζ-potential decreased from 56.48 mV (CMP) to 31.52 mV (CNP). High resolution transmission electron microscopy (HRTEM) revealed nanosize, irregular shap...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-07, Vol.154, p.166-172
Main Authors: Wani, Touseef Ahmed, Masoodi, F.A., Akhter, Rehana, Sofi, Feroz Ahmad
Format: Article
Language:English
Subjects:
Absorption, Physicochemical
Chitosan
Chitosan - chemistry
HDSC
Molecular Weight
Nanoparticles - chemistry
Nanoparticles, size reduction
Nanotechnology
Particle Size
Planetary ball milling
Polymers
Temperature
Water - chemistry
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Summary:Planetary ball milling of chitosan microparticles (CMP) for 8 h produced chitosan nanoparticles (CNP) having hydrodynamic diameter of 615.18 nm. The ζ-potential decreased from 56.48 mV (CMP) to 31.52 mV (CNP). High resolution transmission electron microscopy (HRTEM) revealed nanosize, irregular shape and surface roughening of CNP. CNP was whiter than CMP having higher water absorption capacity and decreased flow ability. Both CMP and CNP showed negligible swelling and no water solubility. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) revealed no chemical changes and X–ray diffraction (XRD) showed decreased crystallinity in CNP. In CNP, thermogravimetric analysis (TGA) revealed increased thermal degradation; differential thermogravimetric (DTG) revealed increased rate of thermal degradation; and high temperature differential scanning calorimetry (HDSC) revealed broadening of endothermic and exothermic phases and reduction in glass transition temperature as compared to CMP. In conclusion, planetary ball milling for 8 h produces bright, amorphous and rough CNP with improved functional and comparable thermal properties. •Planetary ball milling (PBM) produces chitosan nanoparticles (CNP) within 8 h.•Ball milling causes roughening of CNP surface.•CNP have negligible swelling and no water solubility.•PBM causes no chemical changes in CNP but decreases crystallinity.•CNP have broader thermal phases and reduced glass transition temperature.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.03.034