pH-sensitive natural almond gum hydrocolloid based magnetic nanocomposites for theragnostic applications

In this study, iron oxide (γFe2O3) nanoparticles synthesized via hydrothermal route and doxorubicin (Dox) were successfully encapsulated into natural almond gum hydrocolloids via antisolvent precipitation technique. Cubic γFe2O3 crystal structure of the synthesized iron oxide nanoparticles were conf...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2020-07, Vol.154, p.256-266
Main Authors: Jaison, D., Chandrasekaran, Gopalakrishnan, Mothilal, M.
Format: Article
Language:English
Subjects:
Almond gum
Anti-solvent
Antibiotics, Antineoplastic - administration & dosage
Colloids - therapeutic use
Doxorubicin - administration & dosage
Drug Carriers - therapeutic use
Drug Liberation
Ferric Compounds - therapeutic use
HeLa Cells
Humans
Magnetite Nanoparticles - therapeutic use
Nanocomposites - therapeutic use
Natural hydrocolloids
pH responsive
Plant Gums - therapeutic use
Theranostic Nanomedicine
γFe2O3
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, iron oxide (γFe2O3) nanoparticles synthesized via hydrothermal route and doxorubicin (Dox) were successfully encapsulated into natural almond gum hydrocolloids via antisolvent precipitation technique. Cubic γFe2O3 crystal structure of the synthesized iron oxide nanoparticles were confirmed using X-ray diffraction and X-ray photoelectron spectroscopy. The refinement of XRD and elemental analysis revealed oxygen vacancies, which is also indicated by an increased magnetization comparable to bulk γFe2O3. Magnetization studies revealed the superparamagnetic nature of IO and IODPC nanoparticles. The particles were characterized for its morphology (TEM and FESEM), size (FESEM, DLS), surface charge (DLS) and MRI (proton relaxation). The heating ability of the IO and IODPC nanoparticles was studied and their specific absorption rate was found to be 83.06 W/g and 154.37 W/g respectively. The entrapment efficiency of the IODPC nanoparticles was found to be 88.29%. The drug release studies revealed that IODPC nanoparticles were more responsive towards acidic pH and their release follows Higuchi diffusion kinetics. In-vitro uptake and in-vitro cell viability studies were performed for IODPC nanoparticles using HeLA cell lines.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.03.103