Bioactive and adhesive properties of multilayered coatings based on catechol-functionalized chitosan/hyaluronic acid and bioactive glass nanoparticles

Chitosan and hyaluronic acid are the most attractive natural polysaccharides used for tissue regeneration, herein innovative orthopedic coatings were constructed by dip-coating technique. Inspired by the tough nacre-like structure, multifunctional (MF) films were constructed using bioactive glass na...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-08, Vol.157, p.119-134
Main Authors: Almeida, Ana Catarina, Vale, Ana Catarina, Reis, Rui L., Alves, Natália M.
Format: Article
Language:English
Subjects:
Adhesiveness
Bioactive glass
Catechols - chemistry
Chitosan - chemistry
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Glass - chemistry
Guided Tissue Regeneration
Hyaluronic Acid - chemistry
Multilayered adhesive coatings
Nanoparticles - chemistry
Natural polysaccharides
Science & Technology
Viscosity
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Summary:Chitosan and hyaluronic acid are the most attractive natural polysaccharides used for tissue regeneration, herein innovative orthopedic coatings were constructed by dip-coating technique. Inspired by the tough nacre-like structure, multifunctional (MF) films were constructed using bioactive glass nanoparticles (BGNPs) as the inorganic phase and hyaluronic acid (HA) and chitosan (CHT) polymers as the organic phase. Polymeric (CTR) films were also built with both polysaccharides. Inspired by the marine mussel's adhesive proteins, it was the first time that multilayered coatings containing both HA and CHT catechol conjugates were combined with BGNPs. Both catechol-conjugates were successful synthesized and, particularly for HA, it was possible to achieve the double of the substitution degree varying the reaction time. Prior to the LbL build-up, viscosity and Zeta potential measurements of the polyelectrolytes were conducted. The in-situ LbL growth of the films was monitored by quartz crystal microbalance with dissipation monitoring. It was found that the combination of both catechol conjugates resulted in a more compact LbL structure. It was also shown that MF evidenced bioactivity, CTR presented an improved adhesion, and preliminary cellular tests confirmed the biomedical potential of these multilayered coatings being used in orthopedic implants. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.04.095