Graft copolymerization of polyvinylpyrollidone onto Azadirachta indica gum polysaccharide in the presence of crosslinker to develop hydrogels for drug delivery applications

• Published in: International journal of biological macromolecules 2020-09, Vol.159, p.264-275
• Main Authors: Singh, Baljit, Singh, Baldev
• Format: Article
• Language: English
• Subjects: Azadirachta - chemistry; Azadirachta indica gum; Carbon-13 Magnetic Resonance Spectroscopy; Chemical Phenomena; Cross-Linking Reagents - chemistry; Drug Carriers - chemistry; Drug delivery; Drug Delivery Systems; Drug Liberation; Hydrogels; Hydrogels - chemistry; Microscopy, Atomic Force; Plant Gums - chemistry; Poly vinylpyrollidone; Polymerization; Polysaccharides - chemistry; Povidone - chemical synthesis; Povidone - chemistry; Prednisolone - administration & dosage; Prednisolone - analogs & derivatives; Prednisolone - pharmacokinetics; Spectroscopy, Fourier Transform Infrared
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2020.05.091

In this work, graft-copolymerization of poly vinylpyrollidone onto Azadirachta indica gum polysaccharide in the presence of crosslinker has been carried out to prepare the hydrogel for use in drug delivery. The polymers were characterized by cryo-SEM, AFM, FTIR, and 13C NMR. The gel strength, cross-link density, mesh size, thrombogenicity, antioxidant and mucoadhesion properties of the gum-PVP hydrogels were determined along with the evaluation of drug release profile of methyl prednisolone, a colonic anti-inflammatory agent, from the drug loaded hydrogels. Cryo SEM images showed the porous crosslinked structure of the polymer network. The drug release from the polymer followed non-Fickian diffusion mechanism. The polymers showed 71.47 ± 4.63% haemo-compatibility and 05.52 ± 0.59 Nmm gel strength. The value of DPPH radical scavenging assay (73.16 ± 04.85%) indicated that the gum-PVP polymers are antioxidant. The results of biocompatibility, antioxidant activity, mucoadhesion and drug release properties of the polymers inferred the use of this drug carrier for colonic drug delivery. •Polysaccharide gels were obtained by graft polymerization technique.•Gels showed pH responsive swelling and drug release.•The composition of the PVP in the hydrogel influenced the porosity.•Drug release occurred by non-Fickian diffusion mechanism and best fitted in Korsmeyer-Peppas kinetic model.•Hydrogels showed mucoadhesive and non haemolytic behaviour.