Thyroxine impregnated chitosan-based dressings stimulate angiogenesis and support fast wounds healing in rats: Potential clinical candidates

This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed b...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-10, Vol.160, p.296-306
Main Authors: Shahzadi, Lubna, Bashir, Mustehsan, Tehseen, Saimoon, Zehra, Mubashra, Mehmood, Azra, Chaudhry, Aqif Anwar, Rehman, Ihtesham ur, Yar, Muhammad
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Bandages
Cells, Cultured
Chitosan
Chitosan - chemistry
Chorioallantoic Membrane - chemistry
Freeze gelation
Neovascularization, Physiologic - drug effects
Porosity
Rats
Spectroscopy, Fourier Transform Infrared - methods
Thyroxine
Thyroxine - chemistry
Thyroxine - pharmacology
Wound healing
Wound Healing - drug effects
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Summary:This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed by scanning electron microscopy (SEM) and chemical structures were investigated by Fourier transform infra-red spectroscopy (FTIR). Cell culture studies showed materials were non-toxic and chorioallantoic membranes assay (CAM) confirmed that the thyroxine loaded chitosan stimulated angiogenesis much higher than simple chitosan dressings. In addition, thyroxine loaded dressings showed excellent wound healing potential when tested on full thickness rats wounds. A good epithelialization was obtained along with robust wound closure. Overall, as compared to chitosan, thyroxine containing membranes showed high level of angiogenesis and fast wound healing. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.05.127