Assessment of catalytic, antimicrobial and molecular docking analysis of starch-grafted polyacrylic acid doped BaO nanostructures

The removal of cationic dyes from water has received a great attention of researchers considering their influence on environment and ecosystem. In current work, starch-grafted-poly acrylic acid (St-g-PAA) doped BaO nanostrucutures have been synthesized by co-precipitation approach. The aim of this r...

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Published in:International journal of biological macromolecules 2023-03, Vol.230, p.123190, Article 123190
Main Authors: Ikram, Muhammad, Haider, Ali, Imran, Muhammad, Haider, Junaid, Naz, Sadia, Ul-Hamid, Anwar, Shahzadi, Anum, Ghazanfar, Kinza, Nabgan, Walid, Moeen, Sawaira, Ali, Salamat
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
BaO
Catalysis
Ecosystem
Escherichia coli
Methylene Blue - chemistry
Molecular Docking Simulation
Nanocomposites
Starch
Starch - chemistry
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Summary:The removal of cationic dyes from water has received a great attention of researchers considering their influence on environment and ecosystem. In current work, starch-grafted-poly acrylic acid (St-g-PAA) doped BaO nanostrucutures have been synthesized by co-precipitation approach. The aim of this research was to reduce the harmful methylene blue dye and evaluate the antibacterial activity of St-g-PAA doped BaO. XRD spectra exhibited the tetragonal structure of BaO and no variations occurred upon doping. The optical properties of St-g-PAA doped BaO have been evaluated by UV–Vis spectrophotometer. The existence of a dopant in the product was verified using EDS spectroscopy. TEM revealed the formation of cubic-shaped NPs of BaO and upon the addition of St-g-PAA, a few nanorod-like structures. The higher concentration of St-g-PAA doped BaO exhibit a remarkable reduction of methylene blue in a basic environment. Furthermore, St-g-PAA doped BaO revealed higher antimicrobial efficacy against Staphylococcus aureus in comparison to Escherichia coli. In silico studies were conducted against enoyl-[acylcarrier-protein] reductase (FabI) and beta-lactamase enzyme to evaluate the potential of both St-g-PAA and St-g-PAA doped BaO nanocomposites as their inhibitors and to rationalize their possible mode of action. Synthesized St-g-PAA doped BaO for catalytic and bactericidal behavior with molecular docking analysis. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.123190