Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension

Background: Risk factors for atherosclerosis such as hypertension, type 2 diabetes, obesity and dyslipidemia affect endothelial function and stimulate adhesion molecules expression. The aim of the study was to examine endothelial activation in type 2 diabetes and hypertension as indicated by adhesio...

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Published in:International journal of cardiology 2005-01, Vol.98 (1), p.39-44
Main Authors: Boulbou, Mary S., Koukoulis, George N., Makri, Erini D., Petinaki, Efthymia A., Gourgoulianis, Konstantinos I., Germenis, Anastasios E.
Format: Article
Language:English
Subjects:
Adhesion molecules
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
E-Selectin - blood
Endothelium, Vascular - metabolism
Female
Humans
Hypertension
Hypertension - blood
Hypertension - physiopathology
Intercellular Adhesion Molecule-1 - blood
Male
Medical sciences
Middle Aged
Myocardial Contraction
Retrospective Studies
Vascular Cell Adhesion Molecule-1 - blood
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Summary:Background: Risk factors for atherosclerosis such as hypertension, type 2 diabetes, obesity and dyslipidemia affect endothelial function and stimulate adhesion molecules expression. The aim of the study was to examine endothelial activation in type 2 diabetes and hypertension as indicated by adhesion molecule levels and further to investigate whether the coexistence of the above conditions has a different effect. Methods: Serum levels of soluble E-selectin, ICAM-1 and VCAM-1 were measured in 17 hypertensive type 2 diabetic patients (DM-HY), 32 normotensive type 2 diabetic patients (DM), 11 hypertensive nondiabetic patients (HY) and 15 healthy subjects. Results: In diabetic patients (either DM-HY or DM), soluble E-selectin levels were significantly increased compared to healthy subjects ( p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.07.037