Hymenoptera sting-induced Kounis syndrome: Effects of aspirin and β-blocker administration

Abstract Kounis syndrome is the concurrence of acute coronary syndromes with conditions associated with activation of interacting inflammatory cells including allergic or hypersensitivity and anaphylactic or anaphylactoid insults. It is caused via inflammatory mediators released during inflammatory...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology 2007-09, Vol.121 (1), p.105-108
Main Authors: Ioannidis, Tzanetos I, Mazarakis, Andreas, Notaras, Stavros P, Karpeta, Maria Z, Tsintoni, Asimina C, Kounis, George N, Rallis, Dimitrios G, Kounis, Nicholas G
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aged
Allergic angina
Allergic myocardial infarction
Angina Pectoris - immunology
Animals
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Coronary Artery Disease - drug therapy
Coronary heart disease
Coronary Vasospasm - immunology
Heart
Humans
Hymenoptera
Insect Bites and Stings - complications
Kounis syndrome
Male
Medical sciences
Metoprolol - therapeutic use
Myocardial Infarction - immunology
Myocarditis. Cardiomyopathies
Syndrome
Tryptases - blood
Urticaria - immunology
Wasps
β-blockers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Kounis syndrome is the concurrence of acute coronary syndromes with conditions associated with activation of interacting inflammatory cells including allergic or hypersensitivity and anaphylactic or anaphylactoid insults. It is caused via inflammatory mediators released during inflammatory cell activation. A variety of conditions, drugs, and environmental exposures can induce Kounis syndrome. A patient suffering from coronary artery disease and taking metoprolol and aspirin was stung by wasps and developed cutaneous allergic signs including rash, urticaria and orbital oedema. This was followed by retrosternal pain, chest discomfort and electrocardiographic changes compatible with acute myocardial ischemia. Cardiac enzymes, troponins and blood pressure remained normal but serum tryptase was raised. The clinical implications and pathophysiology of this rare association are discussed.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2006.08.039