Primary cardiac lymphoma

Abstract Primary cardiac lymphoma (PCL) is a very rare disorder. Histologically, the majority of cases of PCL are diffuse B-cell lymphoma. PCL occurs more frequently in immunocompromised patients. Symptoms may vary according to the heart site involved. The most frequent cardiac clinical manifestatio...

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Bibliographic Details
Published in:International journal of cardiology 2011-06, Vol.149 (3), p.358-363
Main Authors: Miguel, Carlos E, Bestetti, Reinaldo B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac
Cardiology. Vascular system
Cardiovascular
Diagnosis
Heart Neoplasms - diagnosis
Heart Neoplasms - surgery
Heart Neoplasms - therapy
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma
Lymphoma - diagnosis
Lymphoma - surgery
Lymphoma - therapy
Medical sciences
Primary
Treatment
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Description
Summary:Abstract Primary cardiac lymphoma (PCL) is a very rare disorder. Histologically, the majority of cases of PCL are diffuse B-cell lymphoma. PCL occurs more frequently in immunocompromised patients. Symptoms may vary according to the heart site involved. The most frequent cardiac clinical manifestations associated with PCL are pericardial effusion, heart failure, and atrioventricular block (AV-block). Diagnosis of PCL can be suggested by transesophageal echocardiography, computed tomography, and magnetic resonance imaging. However, cytologic examination of cardiac tumor or pericardial effusion is paramount for a definite diagnosis of this condition. Prognosis of PCL is poor with a median survival of 7 months after initial diagnosis. Newer modalities including immunotherapy with rituximab or auto stem cell transplantation are promising in the treatment of this lethal condition.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2010.02.016