Glucose detection by gold modified carboxyl-functionalized graphene quantum dots-based surface plasmon resonance

• Published in: Optik (Stuttgart) 2021-08, Vol.239, p.166779, Article 166779
• Main Authors: Rosddi, Najwa Norimanina Muhammad, Fen, Yap Wing, Omar, Nur Alia Sheh, Anas, Nur Ain Asyiqin, Hashim, Hazwani Suhaila, Ramdzan, Nur Syahira Md, Fauzi, Nurul Illya Mohd, Anuar, Muhammad Fahmi, Daniyal, Wan Mohd Ebtisyam Mustaqim Mohd
• Format: Article
• Language: English
• Subjects: Glucose; Graphene; Nanocrystalline cellulose; Surface plasmon resonance; Thin film
• ISSN: 0030-4026; 1618-1336
• DOI: 10.1016/j.ijleo.2021.166779

In this work, a graphene quantum dots composite thin film-based surface plasmon resonance (SPR) sensor was developed and experimentally demonstrated for glucose detection. The proposed work incorporates the modification of SPR gold film with carboxyl-functionalized graphene quantum dots-nanocrystalline cellulose (CGQDs-NCC) to improve the detection sensitivity of glucose. The sensing performances of gold/CGQDs-NCC thin film as a function of the sensitivity and binding affinity were analysed. The experimental results show that the linear response of the gold/CGQDs-NCC thin film were 13.296° μM−1, 0.13983° μM−1 and 0.00753° μM−1 for the 0 μM to 0.03 μM, 0.03 μM to 0.5 μM and 0.5 μM–10 μM of glucose concentrations, respectively. The binding affinity has been analyzed using Langmuir and Sips model where it revealed that gold/CGQDs-NCC thin film has higher affinity constant as compared to unmodified gold film. All in all, this paper gives the idea that the introduction of gold-modified CGQDs-NCC thin film in SPR has good potential for detecting glucose solution.