Prevalence of EBV infection in 1157 diseased cohorts in Nigeria: A systematic review and meta-analysis

Epstein-Barr virus (EBV) is a member of the herpesvirus family that is known to ubiquitously infect people worldwide. However, the actual prevalence of EBV infection in diseased patients in Nigeria, remains unknown. This study was thus conducted to ascertain the true prevalence. A systematic review...

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Bibliographic Details
Published in:Indian journal of medical microbiology 2022-07, Vol.40 (3), p.420-426
Main Authors: Irekeola, Ahmad Adebayo, E.A.R., Engku Nur Syafirah, Wada, Yusuf, Mohamud, Rohimah, Mat Lazim, Norhafiza, Yean, Chan Yean, Shueb, Rafidah Hanim
Format: Article
Language:English
Subjects:
Epstein-Barr virus
Meta-analysis
Nigeria
Prevalence
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Summary:Epstein-Barr virus (EBV) is a member of the herpesvirus family that is known to ubiquitously infect people worldwide. However, the actual prevalence of EBV infection in diseased patients in Nigeria, remains unknown. This study was thus conducted to ascertain the true prevalence. A systematic review and meta-analysis of published data was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar were searched for studies reporting the occurrence of EBV infection among patients with established diseases. Studies were included if they assessed EBV infection in diseased patients in Nigeria. Data were extracted and subsequently analysed using R software. Funnel plot and Egger's regression test was used to assess publication bias, while JBI prevalence tool was used to assess study quality. A total of 13 studies covering 228 cases of EBV infection among 1157 diseased patients were included. Summary estimates were computed using random-effects model. The pooled prevalence of EBV infection was 20.3% (95% CI: 10.8–34.9, I2 ​= ​92.26, p ​
ISSN:0255-0857
DOI:10.1016/j.ijmmb.2022.03.008