Fast atom bombardment mass spectral analysis of three new oxidative products of primaquine

FAB mass spectrum of 5,5-di-[6-methoxy-8-(4′-amino-1′butyl amino)] quinoline (PI) was recorded in three different concentrations to establish the structure of new oxidative products of primaquine and also the effect of matrix on percentage relative abundance of molecular as well as fragment ions whi...

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Bibliographic Details
Published in:International journal of mass spectrometry 2004-03, Vol.232 (2), p.151-163
Main Authors: Sinha, Sukesh N, Dua, V.K
Format: Article
Language:English
Subjects:
Anti-malarial drug
FAB mass spectrometry
In vitro
In vivo
Matrix effect
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Summary:FAB mass spectrum of 5,5-di-[6-methoxy-8-(4′-amino-1′butyl amino)] quinoline (PI) was recorded in three different concentrations to establish the structure of new oxidative products of primaquine and also the effect of matrix on percentage relative abundance of molecular as well as fragment ions which were demonstrated first time. At three concentrations, three different behaviors of matrix, molecular and fragment ions were observed. At higher concentration (>1 nM) molecular ion behaved as a base peak, but due to side reaction with matrix certain extra peak were also obtained. Thus, the higher concentration was interesting to show the side reaction of analyte with m-nitro-benzyl alcohol (NBA) but not for molecular weight determination. At the lowest concentration (
ISSN:1387-3806
1873-2798
DOI:10.1016/j.ijms.2003.11.013