An electrostatic focusing ion guide for ion mobility-mass spectrometry

An electrostatic focusing ion guide ion mobility-mass spectrometer (IM-MS) is described. The apparatus consists of a MALDI ion source coupled to an ion drift cell operating at pressures of 1–10 Torr and a small linear time-of-flight (TOF) mass spectrometer. The electrostatic focusing IMS drift cell...

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Bibliographic Details
Published in:International journal of mass spectrometry 2004-12, Vol.239 (1), p.43-49
Main Authors: Gillig, Kent J., Ruotolo, Brandon T., Stone, Earle G., Russell, David H.
Format: Article
Language:English
Subjects:
Electrostatic focusing ion guide
Ion mobility spectrometry
Mass spectrometry
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Description
Summary:An electrostatic focusing ion guide ion mobility-mass spectrometer (IM-MS) is described. The apparatus consists of a MALDI ion source coupled to an ion drift cell operating at pressures of 1–10 Torr and a small linear time-of-flight (TOF) mass spectrometer. The electrostatic focusing IMS drift cell acts as an ion guide, thus increasing ion transmission while maintaining high resolution. The drift cell is composed of a series of focusing and defocusing electrostatic fields superimposed on the potential drop applied across the drift cell. Calculated ion trajectories for several drift cell configurations, which include Monte Carlo simulations to model ion-neutral collisions, show significantly higher ion transmission and these results are supported by preliminary experimental results. A mobility resolution of ∼100 and detection levels of
ISSN:1387-3806
1873-2798
DOI:10.1016/j.ijms.2004.09.005