Design and development of a scanning magnet for high-resolution mass spectrometry

The magnets play a crucial role in sector mass spectrometers, directly influencing the resolution, sensitivity, and stability of these instruments. This study is based on the design requisites for high-resolution scanning magnet, alongside the optical layout schematics for mass spectrometer instrume...

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Bibliographic Details
Published in:International journal of mass spectrometry 2024-10, Vol.504, p.117308, Article 117308
Main Authors: Wang, Zhiqiang, Li, Yurong, Fang, Yingtong, Liao, Yicheng, Qin, Bin, Ma, Jing, Hou, Liudong, Qin, Yongquan, Liu, Quanwei
Format: Article
Language:English
Subjects:
Dynamic characteristics analysis
Magnetic field homogeneity
Magnetic mass spectrometry
Scanning magnet
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Summary:The magnets play a crucial role in sector mass spectrometers, directly influencing the resolution, sensitivity, and stability of these instruments. This study is based on the design requisites for high-resolution scanning magnet, alongside the optical layout schematics for mass spectrometer instrumentation. The analysis is conducted on the design parameters encompassing magnetic structure, field quality, and response dynamics. Utilizing Opera-3D simulation software, optimization designs are executed for the magnetic structure and performance, resulting in a magnet design exhibiting commendable attributes such as response time, magnetic field distortion characteristics, field range, linearity, and homogeneity. Following the completion of magnet fabrication and assembly, comprehensive evaluations of magnetic field performance and instrument testing are conducted. Results demonstrate good magnetic field linearity and minimal eddy current distortion, with a magnetic field homogeneity reaching up to ±0.05 % within the desired field region. The magnet exhibits versatility across a scan range spanning 7 to 238 u, with a scanning speed of 140 ms. Sensitivity and resolution tests, conducted using In-115, validated the magnet's compliance with the stringent design requirements of high-resolution mass spectrometry scanning magnets. [Display omitted] •Technological Advancements in High-Resolution Mass Spectrometry.•Magnet Design Optimization: structural materials, static magnetic field and dynamic magnetic field optimization.•Performance Evaluation and Experimental Validation: enhanced both resolution and scanning speed of the HR-MS.
ISSN:1387-3806
DOI:10.1016/j.ijms.2024.117308