Novel sensitive electrochemical detection of paracetamol using magnetite/MXene electrode by differential pulse voltammetry

• Published in: International journal of electrochemical science 2024-10, Vol.19 (10), p.100797, Article 100797
• Main Authors: Alkhudaydi, Amal M., Samy, Basel A., Danish, Ekram Y., Lima, Eder Claudio, Gabal, M.A., Salam, Mohamed Abdel
• Format: Article
• Language: English
• Subjects: Electrochemical detection; Magnetite; Mxene; Paracetamol
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/j.ijoes.2024.100797

In this research work, a novel electrochemical sensor-based Fe3O4/Ti3C2 MXene @ glassy carbon electrode (GCE) for the detection of paracetamol was prepared by simple ultrasonic method by combining Ti3C2 MXene and Fe3O4 nanoparticles. The Fe3O4/Ti3C2 MXene nanomaterial was characterized by the means of different techniques: X-ray diffraction (XRD), transmission and scanning electron microscopy (TEM), nitrogen adsorption/desorption isotherms, as well as Fourier transform infrared spectroscopy (FTIR). The characterization results revealed the homogenous distribution of the prepared cubic Fe3O4 NPs within the prepared two-dimensional layered Ti3C2 MXene. The Fe3O4/Ti3C2 MXene @ GCE was used for the sensitive determination of the well-known analgesic drug paracetamol by differential pulse voltammetry (DPV). The prepared Fe3O4/Ti3C2 MXene @ GCE was characterized electrochemically, and the results showed that Fe3O4/Ti3C2 MXene @ GCE is a potential working electrode for the sensitive detection of paracetamol with very low detection limit (0.63 nM), within a linear dynamic range of 0.0–110.0 µM, high reproducibility and repeatability; with a very low relative standard deviation (SD%) for 7 days measurement (3.07–3.42 %), accuracy with a SD% of 0.89, high precision of 99.48 % in distilled water and 98.51 % in sea water. The proposed electroanalytical method was applied for the detection and quantification of paracetamol in real water samples, as well as different analgesic medical formulations, and the results showed outstanding accuracy and precision indicating the suitability of the Fe3O4/Ti3C2 MXene @ GCE electrode for the sensitive, accurate determination of paracetamol in diferrent matrices. [Display omitted] •A novel Fe3O4@Ti3C2 MXene nanophotocatalyst was prepared by simple ultrasonic method.•Fe3O4@Ti3C2 MXene nanophotocatalyst was characterized fully.•The sensor-based Fe3O4/Ti3C2 MXene @ GCE for the detection of paracetamol.•The method showed high reproducibility, repeatability, accuracy, precision, and very low detection limit.