Long-term control of lung metastasis of tongue cancer treated effectively with cetuximab combination chemotherapy

Oral squamous cell carcinoma with distant metastasis is generally treated with systemic chemotherapy and has a poor prognosis. The recent introduction of molecular targeted drugs such as cetuximab and of immune checkpoint inhibitors has dramatically improved the prognosis, although the control of di...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2023-12, Vol.52 (12), p.1221-1224
Main Authors: Terabe, T., Ishibashi-Kanno, N., Uchida, F., Bukawa, H.
Format: Article
Language:English
Subjects:
Cetuximab
Head and neck squamous cell carcinoma
Neoplasm metastasis
Oral squamous cell carcinoma
Tongue cancer
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Summary:Oral squamous cell carcinoma with distant metastasis is generally treated with systemic chemotherapy and has a poor prognosis. The recent introduction of molecular targeted drugs such as cetuximab and of immune checkpoint inhibitors has dramatically improved the prognosis, although the control of distant metastasis remains challenging. The case of a patient with tongue cancer in which lung metastases disappeared in the long term is reported here. A 60-year-old Japanese man with squamous cell carcinoma of the tongue underwent preoperative chemoradiotherapy and surgery including subtotal glossectomy, bilateral modified radical neck dissection, and immediate reconstruction with an anterolateral thigh flap. One month after surgery, multiple nodules of
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2023.07.001