Preparation and characterization of poly-ɛ-caprolactone nanoparticles containing griseofulvin

Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this work was to prepare poly-ɛ-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and to characterize them. Nanoparticles of griseofulvin were obtained with high encapsulation ef...

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Bibliographic Details
Published in:International journal of pharmaceutics 2005-04, Vol.294 (1), p.261-267
Main Authors: Zili, Zohra, Sfar, Souad, Fessi, Hatem
Format: Article
Language:English
Subjects:
Characterization
Dissolution rate
Griseofulvin
Nanocapsules
Nanospheres
Preparation
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Summary:Griseofulvin is an antifungal agent with poor solubility and low bioavailability. The aim of this work was to prepare poly-ɛ-caprolactone nanospheres and nanocapsules of griseofulvin by nanoprecipitation and to characterize them. Nanoparticles of griseofulvin were obtained with high encapsulation efficiency. The particle size was about 250–326 nm for nanospheres and 390–400 nm for nanocapsules. The dissolution rate of griseofulvin nanoparticles was higher than that of micronized griseofulvin therefore recourse to nanoencapsulation of griseofulvin should enhance its bioavailability and possibly its efficiency for the treatment of dermatomycosis.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2005.01.020