Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

[Display omitted] The aim of this study was to investigate the influence of the nanocarrier surface charge on brain delivery of a model hydrophilic drug via the nasal route. Anionic and cationic nanostructured lipid carriers (NLCs) were prepared and optimized for their particle size and zeta potenti...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-10, Vol.473 (1-2), p.442-457
Main Authors: Gabal, Yasmine M., Kamel, Amany O., Sammour, Omaima A., Elshafeey, Ahmed H.
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animals
Antiparkinson Agents - administration & dosage
Antiparkinson Agents - blood
Antiparkinson Agents - chemistry
Antiparkinson Agents - pharmacokinetics
Brain - metabolism
Brain delivery
Calorimetry, Differential Scanning
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Gels
In vivo
Indoles - administration & dosage
Indoles - blood
Indoles - chemistry
Indoles - pharmacokinetics
Intranasal
Lipids - administration & dosage
Lipids - chemistry
Male
Microscopy, Electron, Transmission
Nanostructured lipid carriers
Nanostructures - administration & dosage
Nanostructures - chemistry
Nasal Mucosa - pathology
Particle Size
Rats, Wistar
Surface charge
Surface Properties
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Summary:[Display omitted] The aim of this study was to investigate the influence of the nanocarrier surface charge on brain delivery of a model hydrophilic drug via the nasal route. Anionic and cationic nanostructured lipid carriers (NLCs) were prepared and optimized for their particle size and zeta potential. The optimum particles were incorporated in poloxamer in situ gels and their in vivo behavior was studied in the plasma and brain after administration to rats. Optimum anionic and cationic NLCs of size
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.07.025