Cinnamate of inulin as a vehicle for delivery of colonic drugs

[Display omitted] Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach colon; in addition, intravenous administrated drugs are eliminated from the body before reaching colon. Inulin is a naturally occurring poly...

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Bibliographic Details
Published in:International journal of pharmaceutics 2015-02, Vol.479 (1), p.96-102
Main Authors: López-Molina, Dorotea, Chazarra, Soledad, How, Chee Wun, Pruidze, Nikolov, Navarro-Perán, Enma, García-Cánovas, Francisco, García-Ruiz, Pedro Antonio, Rojas-Melgarejo, Francisco, Rodríguez-López, José Neptuno
Format: Article
Language:English
Subjects:
Apoptosis - drug effects
Caco-2 Cells
Cell Survival - drug effects
Cichorium intybus
Cinnamates - chemistry
Cinnamoylated inulin
Colon - metabolism
Colon drug delivery
Drug Delivery Systems
Drug Liberation
Glycoside Hydrolases - chemistry
Humans
Inulin
Inulin - administration & dosage
Inulin - chemistry
Inulinase
Methotrexate
Methotrexate - administration & dosage
Methotrexate - chemistry
Microspheres
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Summary:[Display omitted] Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach colon; in addition, intravenous administrated drugs are eliminated from the body before reaching colon. Inulin is a naturally occurring polysaccharide found in many plants. It consists of β 2-1 linked d-fructose molecules having a glucosyl unit at the reducing end. Various inulin and dextran hydrogels have been developed that serve as potential carrier for introduction of drugs into the colon. Because inulin is not absorbed in the stomach or in the small intestine, and inulin is degraded by colonic bacteria, drugs encapsulated in inulin-coated vesicles could be specifically liberated in the colon. Therefore, the use of inulin-coated vesicles could represent an advance for the treatment of colon diseases. Here, we study the use of a cinnamoylated derivative of chicory inulin as a vehicle for the controlled delivery of colonic drugs. The encapsulation of methotrexate in inulin vesicles and its release and activity was studied in colon cancer cells in cultures.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.12.064