Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing

• Published in: International journal of pharmaceutics 2020-03, Vol.578, p.118805, Article 118805
• Main Authors: Clark, Elizabeth A., Alexander, Morgan R., Irvine, Derek J., Roberts, Clive J., Wallace, Martin J., Yoo, Jae, Wildman, Ricky D.
• Format: Article
• Language: English
• Subjects: Additive manufacturing; Carvedilol; Delivery of a poorly soluble drug; Inkjet 3D printing; Personalized medicine; Tablet; UV photopolymerization
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2019.118805

[Display omitted] In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959, and a photocurable N-vinyl-2-pyrrolidone (NVP) and poly(ethylene glycol) diacrylate matrix, with the intention of forming an amorphous solid solution for release of carvedilol. Characterization of the printed tablets showed that the drug is an amorphous state and indicated hydrogen bonding interactions between the drug and cross-linked matrix. Several simple geometries (ring, mesh, cylinder, thin film) were printed, and the surface area to volume ratio of the prints was estimated. Over 80% carvedilol release was observed for all printed tablet geometries within ten hours. The release behaviour of carvedilol was fastest for the thin films, followed by the ring and mesh geometries, and slowest in the cylindrical forms. More rapid release was correlated to an increased surface area to volume ratio. This is the first study to implement 3D UV inkjet to make solid dispersion tablets suitable for poorly soluble drugs. Results also demonstrate that high drug-loaded tablets with a variety of release profiles can successfully be accessed with the same UV-curable inkjet formulation by varying the tablet geometry.