Case report: A rare case of dual primary synchronous malignancies of the breast and kidney in a 70 year female

• Published in: International journal of surgery case reports 2024-03, Vol.116, p.109400, Article 109400
• Main Authors: Hamid, Tarbia, Khan, Fatima, Khattak, Nuzhat Sultana, Kakakhel, Mian Naushad Ali, Hamid, Ramsha
• Format: Article
• Language: English
• Subjects: Breast cancer; Breast surgery; Case report; Multidisciplinary team; Renal cell cancer; Synchronous primary cancers
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2024.109400

Multiple primary cancers (MPCs) have attracted attention in medical research due to their increasing incidence. The coexistence of invasive breast carcinoma and clear cell carcinoma of the kidney, alongside a family history of cancer, highlights the multifactorial origins of MPCs, particularly their potential association with genetic factors. A 70-year-old female initially sought medical attention for a two-year history of a right breast lump as her primary concerns centered on the long-standing lump. Clinical evaluations and imaging studies revealed an invasive breast carcinoma diagnosis, and simultaneously, an incidental mass in her left kidney was identified as clear cell carcinoma. Emphasis and further researh should be on the potential role of genetic factors in MPC development, necessitating comprehensive genetic evaluations. This study highlights the significance of customized treatment approaches for each malignancy, facilitating early detection, improved patient outcomes, and an enhanced understanding of MPCs. •There is an increasing incidence in the rate of multiple primary synchronous tumors.•Genetic and environmental factors contributing to development of multiple primary cancers need to be evaluated.•Clinical presentation of primary breast cancer and primary renal cell carcinoma is very rare.•Multidisciplinary treatment plan for synchronous tumors needs to be formulated and tailored to every patient.