A cross-sectional study on the postoperative analgesic-associated side effects and clinical parameters following partial mastectomy

• Published in: International journal of surgery open 2020, Vol.27, p.114-118
• Main Authors: Alizadeh, Reza, Aghsaeifard, Ziba, Alavi, Nasrin, Abbasvandi, Fereshteh, Khanigarabadi, Ali
• Format: Article
• Language: English
• Subjects: Analgesia; Chronic pain; Lumpectomy; Pain management; Partial mastectomy
• ISSN: 2405-8572; 2405-8572
• DOI: 10.1016/j.ijso.2020.10.018

Lumpectomy (partial mastectomy) is associated with a severe postoperative pain that can lead to chronic pain. The use of analgesia is common for this pain management, however, can impose a number of side effects. The aim of this study is to evaluate side effects following postoperative analgesia use and the impact of clinical factors among partial mastectomy patients. This cross-sectional study was conducted at (XXX) center for breast cancer that included patients undergoing lumpectomy. Following the surgery, patients were given morphine 1 mg/ml with 50 mg diclofenac at every 8-h for 3 days for the management of pain. The visual analogue scale was used to measure pain. Postoperative nausea and vomiting, dizziness and vertigo was evaluated in these patients. The effects of these events on pulse rate, blood pressure and incision size were then analyzed using standard package in R software. Of 136 partial mastectomy patients, an average of 41% of the patients were presented with nausea and vertigo, respectively, 9% had dizziness and 29% had vomiting. The results from our study indicated that clinical parameters (blood pressure, pulse rate and incision size) were not significantly associated with postoperative pain and dizziness p > 0.1. However, blood pressure and pulse are significantly associated with postoperative nausea and vertigo. The findings from our study indicate that hemodynamic variations are likely to be associated with analgesia-associated side effects. Future studies involving other parameters and risk factors can provide detailed outcomes. •Lumpectomy is associated with a severe postoperative pain that can lead to chronic pain.•Clinical parameter was not significantly associated with postoperative pain and dizziness.•Blood pressure and pulse are significantly associated with postoperative nausea and vertigo.•Evaluate postoperative analgesic on clinical parameters in patients undergoing lumpectomy.