Effectiveness of ketofol versus propofol induction on hemodynamic profiles in adult elective surgical patients: A Randomized Controlled Trial

• Published in: International journal of surgery open 2021-12, Vol.37, p.100392, Article 100392
• Main Authors: Hailu, Seyoum, Getachew, Hailemariam, Hailu, Sileshi, Abebe, Teshome, Seifu, Ashenafi, Regassa, Teshome, Girma, Timsel, Dastew, Belete, Zemedkun, Abebayehu, Neme, Derartu, Teshome, Diriba, Tadesse, Muhuddin
• Format: Article
• Language: English
• Subjects: Anesthesia induction; Hemodynamics; Ketofol; Propofol
• ISSN: 2405-8572; 2405-8572
• DOI: 10.1016/j.ijso.2021.100392

Most of the time propofol and ketamine have been used as an induction agent in adult surgical patients but propofol may cause cardiorespiratory depression while ketamine increases heart rate and arterial blood pressure. On the other hand, the clinical effects of propofol and ketamine seem to be complementary. Ketofol is most commonly used for procedural sedation hence exploring its effectiveness for induction will be paramount for the clinical care of surgical patients. This study aims to compare the hemodynamic changes between ketofol and propofol within 30 min after induction of general anesthesia for elective surgical patients. A Double-blind Randomized Controlled Trial was done on 62 patients aged between 18 and 65 years and the American Society of Anesthesiologist class I & II those have been allocated randomly into ketofol and propofol groups. A change in systolic blood pressure, mean arterial pressure, and heart rate within 30mins was followed for both groups. After the normal distribution of data was tested analytic statistics were calculated for variables in the study using Mixed ANOVA, Independent samples T-test, and Mann Whitney U test as appropriate, and for categorical data Chi-square test or fisher's exact test was used for analysis. P-value < 0.05 is considered statistically significant with a power of 90%. Both the mean systolic blood pressure and mean arterial pressure were significantly decreased in the propofol group immediately after induction, at 5th minute, 10th minute, and 15th minute compared to the baseline value with a statistically significant value of (p 20% in SBP from baseline at 5 min.