Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model

Highlights • Psoriatic inflammation causes hepatic inflammation in mice. • Psoriatic inflammation enhances hepatic IL-17RC/NFκB signaling. • Psoriatic inflammation causes dysregulation of hepatic metabolism. • IL-17A blockade reduces hepatic inflammation in psoriatic mice. • rmIL-17A aggravates hepa...

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Bibliographic Details
Published in:Immunobiology (1979) 2017-02, Vol.222 (2), p.128-136
Main Authors: Al-Harbi, Naif O, Nadeem, Ahmed, Al-Harbi, Mohammed M, Zoheir, Khairy M.A, Ansari, Mushtaq A, El-Sherbeeny, Ahmed M, Alanazi, Khalid M, Alotaibi, Moureq R, Ahmad, Sheikh F
Format: Article
Language:English
Subjects:
Advanced Basic Science
Allergy and Immunology
Animals
Biomarkers
Cytokines - metabolism
Disease Models, Animal
Energy Metabolism
Hepatitis - etiology
Hepatitis - metabolism
IL-17 receptor
IL-17A
Interleukin-17 - metabolism
Lipid Metabolism
Lipid Peroxidation
Liver
Male
Mice
NF-kappa B - metabolism
Nuclear factor-kappa B
Oxidative Stress
Peroxidase - metabolism
Psoriasis - complications
Psoriasis - immunology
Psoriasis - metabolism
Psoriatic inflammation
Receptors, Interleukin-17 - metabolism
Signal Transduction
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Summary:Highlights • Psoriatic inflammation causes hepatic inflammation in mice. • Psoriatic inflammation enhances hepatic IL-17RC/NFκB signaling. • Psoriatic inflammation causes dysregulation of hepatic metabolism. • IL-17A blockade reduces hepatic inflammation in psoriatic mice. • rmIL-17A aggravates hepatic inflammation in psoriatic mice.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2016.10.013