PKCδ is involved in signal attenuation in CD3 + T cells

PKCδ has been implicated in the signalling events after engagement of the antigen specific receptor on B cells and the Fc-ɛ receptor on mast cells. Employing our recently established PKCδ null mice [1], we here investigate the physiological function of PKCδ in CD3 + T cells. As result, administratio...

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Bibliographic Details
Published in:Immunology letters 2005-01, Vol.96 (2), p.291-293
Main Authors: Gruber, Thomas, Barsig, Johannes, Pfeifhofer, Christa, Ghaffari-Tabrizi, Nassim, Tinhofer, Inge, Leitges, Michael, Baier, Gottfried
Format: Article
Language:English
Subjects:
Cell cycle regulation
IL-2
PKCδ
T-lymphocyte
TCR/CD3
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Summary:PKCδ has been implicated in the signalling events after engagement of the antigen specific receptor on B cells and the Fc-ɛ receptor on mast cells. Employing our recently established PKCδ null mice [1], we here investigate the physiological function of PKCδ in CD3 + T cells. As result, administration of anti-CD3 antibodies in vivo induced markedly increased blood plasma IL-2 levels (but not IL-4, IFN-γ, TNF-α and IL-6 levels) in the PKCδ null mice, when compared to wild-type sibling controls. Additionally, in vitro T cell proliferative responses to allogenic MHC are significantly enhanced in PKCδ-deficient CD3 + T cells. These findings suggest that PKCδ serves a so far unrecognized role in TCR-induced negative regulation of IL-2 cytokine production and T cell proliferation.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2004.08.011