Ixodicidal compounds from pre-domesticated Lavandula luisieri

[Display omitted] •Pre-domesticated Lavandula luisieri.•Larvicidal effects of plant extracts against the hard tick Hyalomma lusitanicum.•Bioguided fractionation of the hydrolate organic fraction.•The activity of the extracts and fractions correlated with larvicidal necrodanes.•Necrodanes can be a ne...

Full description

Saved in:
Bibliographic Details
Published in:Industrial crops and products 2017-12, Vol.110, p.83-87
Main Authors: Julio, Luis F., Díaz, Carmen E., Aissani, Nadhem, Valcarcel, Felix, Burillo, Jesus, Olmeda, Sonia, González-Coloma, Azucena
Format: Article
Language:English
Subjects:
Essential oil
Hexane
Hyalomma lusitanicum
Hydrolate
Larvicidal
Lavandula luisieri
Necrodane-type
Pre-domesticated
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Pre-domesticated Lavandula luisieri.•Larvicidal effects of plant extracts against the hard tick Hyalomma lusitanicum.•Bioguided fractionation of the hydrolate organic fraction.•The activity of the extracts and fractions correlated with larvicidal necrodanes.•Necrodanes can be a new class of ixodicidal agents. Several extracts from pre-domesticated Lavandula luisieri (Rozeira) Riv-Mart. (Lamiaceae) (essential oil, EO; hexane, Hx and the organic fraction of the residual hydrolate, WRO) showed larvicidal effects against the hard tick Hyalomma lusitanicum, being WRO the most active. Their content in the necrodane-type monoterpenes (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2), 5-hydroxymethyl-2,3,4,4-tetramethylcyclopent-2-en-1-one (1) and 2-(hydroxymethyl)-3,4,4-trimethyl-5-methylenecyclopent-2-en-1-one (5) correlated with these effects. Among the isolated compounds, 3,3,4,5-tetramethyl-2H-pyran-2,6(3H)-dione (7) and (2,2,3,4-tetramethyl-5-oxocyclopent-3-en-1-yl)-methyl acetate (2) were the most potent ones, with activity levels within the range of the positive control thymol. These compounds represent a new class of ixodicidal agents.
ISSN:0926-6690
1872-633X
DOI:10.1016/j.indcrop.2017.06.044