Optimization of chiisanoside and chiisanogenin isolation from Eleutherococcus sessiliflorus (Rupr. & Maxim.) leaves for industrial application: A pilot study

Chiisanoside and chiisanogenin, which have been reported to have various bioactivities, were the most representative components of the leaves of Eleutherococcus sessiliflorus. The purpose of this study was to establish an optimal harvest period to increase bioactive chemical components and to utiliz...

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Bibliographic Details
Published in:Industrial crops and products 2022-10, Vol.185, p.115099, Article 115099
Main Authors: Jang, Hyun-Jae, Kim, Won Jun, Lee, Su Ui, Kim, Mun-Ock, Park, Mi Hyeon, Song, Soobin, Kim, Doo-Young, Lee, Seong Mi, Yuk, Heung Joo, Lee, Dae Young, Hwang, Bang Yeon, Ryu, Hyung Won, Oh, Sei-Ryang
Format: Article
Language:English
Subjects:
Chiisanogenin
Chiisanoside
Eleutherococcus sessiliflorus leaves
Growth stages
Quality control
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Summary:Chiisanoside and chiisanogenin, which have been reported to have various bioactivities, were the most representative components of the leaves of Eleutherococcus sessiliflorus. The purpose of this study was to establish an optimal harvest period to increase bioactive chemical components and to utilize them as industrial crop materials under the quality control process of E. sessiliflorus. The extraction conditions of leaves were optimized to maximize the main two components using response surface methodology with a Box-Behnken design. The chemical structures of compounds 1–18 isolated from leaves under optimal extraction conditions were identified via NMR and HRMS. Using the chemical profile of leaves by the established UPLC-QTOF-MS and PDA methods, the yields of chiisanoside and chiisanogenin were inversely proportional, and the optimal harvest time from April to September was determined as July for those two components. This study could be used to develop high-quality products, including functional medicinal crops and health supplements, using E. sessiliflorus leaves. [Display omitted] •Chemical profile of E. sessiliflorus leaves was identified by QTOF-MS and NMR.•UPLC-PDA method was applied to determine the content of the five components.•Extraction conditions were optimized using response surface methodology.•Optimal harvest time was determined as July for chiisanoside and chiisanogenin.
ISSN:0926-6690
1872-633X
DOI:10.1016/j.indcrop.2022.115099