Synthesis, characterization, and fluorescence and cytotoxicity studies of a tetrarhenium molecular rectangle

The molecular rectangle [(CO) 3Re(μ-OC 5H 11) 2Re(CO) 3] 2{μ-(4,4′-bpy)} 2 ( I), which is cytotoxic against cancer cells, has been synthesized in high yield from one-pot reaction of Re 2(CO) 10 with 4,4′-bpy in refluxed 1-pentanol. An one-pot reaction of Re 2(CO) 10 with 4,4′-bipyridyl (4,4′-bpy) in...

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Bibliographic Details
Published in:Inorganic chemistry communications 2007-07, Vol.10 (7), p.821-824
Main Authors: Orsa, Dejene K., Haynes, Gregory K., Pramanik, Saroj K., Iwunze, Maurice O., Greco, George E., Krause, Jeanette A., Ho, Douglas M., Williams, Arthur L., Hill, Dwayne A., Mandal, Santosh K.
Format: Article
Language:English
Subjects:
Cancer cell lines
Crystal structure
Fluorescence
Molecular rectangle
Rhenium
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Summary:The molecular rectangle [(CO) 3Re(μ-OC 5H 11) 2Re(CO) 3] 2{μ-(4,4′-bpy)} 2 ( I), which is cytotoxic against cancer cells, has been synthesized in high yield from one-pot reaction of Re 2(CO) 10 with 4,4′-bpy in refluxed 1-pentanol. An one-pot reaction of Re 2(CO) 10 with 4,4′-bipyridyl (4,4′-bpy) in refluxed 1-pentanol afforded the molecular rectangle, [(CO) 3Re(μ-OC 5H 11) 2Re(CO) 3] 2{μ-(4,4′-bpy)} 2 ( I), in almost quantitative yield. The molecular rectangle, I, has been characterized spectroscopically and by X-ray crystal structure determination. Compound I exhibits fluorescence and is cytotoxic against cancer cell lines.
ISSN:1387-7003
1879-0259
DOI:10.1016/j.inoche.2007.04.006