Uptake of VIV ion of vanadocene dichloride by apo-transferrin investigated by ESR spectroscopy

The action mechanism of vanadocene dichloride, Cp2VCl2 (Cp=η5-C5H5), has been investigated by interaction with apo-transferrin and albumin for its promising antitumor activities. Our ESR spectral studies clearly showed that VIV ion is readily transported from vanadocene chloride to transferrin, and...

Full description

Saved in:
Bibliographic Details
Published in:Inorganic chemistry communications 2009-03, Vol.12 (3), p.198-200
Main Authors: Nishida, Yuzo, Niinuma, Aki, Abe, Keita
Format: Article
Language:English
Subjects:
Anticancer activity
Apo-transferrin
ESR spectra
Vanadocene dichloride
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The action mechanism of vanadocene dichloride, Cp2VCl2 (Cp=η5-C5H5), has been investigated by interaction with apo-transferrin and albumin for its promising antitumor activities. Our ESR spectral studies clearly showed that VIV ion is readily transported from vanadocene chloride to transferrin, and the VIV ions are captured at the Fe(III) binding sites of transferrin as a VO2+ form. The action mechanism of vanadocene dichloride, Cp2VCl2 (Cpη5-C5H5), has been investigated by interaction with apo-transferrin and albumin for its promising antitumor activities. Our ESR spectral studies clearly showed that VIV ion is readily transported from vanadocene chloride to transferrin, and the VIV ions are captured at the Fe(III) binding sites of transferrin as a VO2+ form. We also observed that some binuclear VO2+ complexes can efficiently transport the VO2+ ions to the apo-transferrin.
ISSN:1387-7003
1879-0259
DOI:10.1016/j.inoche.2008.12.009