Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

• Published in: Inorganic chemistry communications 2012-09, Vol.23, p.63-66
• Main Authors: Ferreira, Janaína G., Stevanato, Alessandra, Santana, Anderson M., Mauro, Antonio E., Netto, Adelino V.G., Frem, Regina C.G., Pavan, Fernando R., Leite, Clarice Q.F., Santos, Regina H.A.
• Format: Article
• Language: English
• Subjects: 1,3-bis(Diphenylphosphino)propane; Mycobacterium tuberculosis; Organometallic Pd(II) compound
• ISSN: 1387-7003; 1879-0259
• DOI: 10.1016/j.inoche.2012.06.007

The organometallic compound [Pd(C-bzan)(SCN)(dppp)] {bzan = N-benzylideneaniline, dppp = 1,3-bis(diphenylphosphino)propane} was synthesized and characterized by elemental analyses, infrared and 1H and 31P{1H} NMR spectroscopies. The crystal and molecular structures of the title complex were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that the compound [Pd(C-bzan)(SCN)(dppp)] displayed a MIC of 5.15μM, which is superior than those values found for some commonly used anti-TB drugs and other Pd(II) complexes. ► The organometallic [Pd(C-bzan)(SCN)(dppp)] compound was synthesized and characterized. ► The structure of [Pd(C-bzan)(SCN)(dppp)] was determined by X-ray diffraction. ► Compound [Pd(C-bzan)(SCN)(dppp)] was highly effective against M. tuberculosis. The synthesis, structure and in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv of the compound [Pd(C-bzan)(SCN)(dppp)] {bzan = N-benzylideneaniline, dppp = 1,3-bis(diphenylphosphino)propane} were presented in this work. The title compound was highly effective against M. tuberculosis, with a MIC value of 5.15μM. [Display omitted]